A Diterpenoid with a New Skeleton and Cytotoxic Terpenoids Isolated from Amentotaxus formosana

✍ Scribed by Huey-Jen Su; Li-Wen Wang; Chun-Nan Lin; Shiow-Hwa Day; Bai-Luh Wei; Sheng-Zehn Yang; Shen-Jeu Won

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: German
• Weight: 108 KB
• Volume: 86
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200390214

✦ Synopsis

Abstract

The new diterpenoid 6__α__‐hydroxy‐ent‐kaur‐16‐en‐15‐one (1) and a diterpenoid with a new skeleton, i.e., amentotaxin BB (5), as well as three new lanostanoids, i.e., (3__β__,23__R__)‐3‐methoxy‐24‐methylenelanost‐8‐en‐23‐ol (6), (23__S__)‐23‐methoxy‐24‐methylenelanost‐8‐en‐3‐one (7), and (3__β__,24__ξ__)‐3‐methoxy‐24‐methyl‐9,19‐cyclolanostan‐25‐ol (8), were isolated from the bark and leaves of Amentotaxus formosana. Their structures, including the relative configurations, were elucidated from spectroscopic data. Compound 1 and a known compound, ent‐kaur‐16‐en‐15‐one (2), showed potent cytotoxic effects against a number of cancer cells in vitro.