✦ LIBER ✦
A dissolution-diffusion model for the TAXUS™ drug-eluting stent with surface burst estimated from continuum percolation
✍ Scribed by Victor Barocas; William Drasler II; Tim Girton; Ismail Guler; David Knapp; Jeff Moeller; Edward Parsonage
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 409 KB
- Volume
- 90B
- Category
- Article
- ISSN
- 1552-4973
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✦ Synopsis
Abstract
A two‐layer dissolution‐diffusion model is derived which incorporates a surface burst component that is estimated from continuum percolation models of overlapping Poisson distributed spheres. The model is shown to adequately describe the release properties of paclitaxel from a hydrophobic polymer matrix, including the surface burst and sustained release dependence on drug loading. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009