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A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) cleaves Reelin in an isoform-dependent manner

✍ Scribed by Arisa Hisanaga; Shunsuke Morishita; Kenta Suzuki; Kazutomo Sasaki; Mari Koie; Takao Kohno; Mitsuharu Hattori

Book ID
118442906
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
699 KB
Volume
586
Category
Article
ISSN
0014-5793

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## Abstract Brain tumors, in particular glioblastomas, have a high morbidity and mortality, mainly due to their invasive nature. A prerequisite for this invasiveness is cell migration based on increased expression of proteases digesting the extracellular matrix. Brevican, an important extracellular