The problem of finding the steady-state volume of distribution V ss for a linear pharmacokinetic system with peripheral drug elimination is considered. A commonly used equation V ss ΒΌ (D/AUC)\*MRT is applicable only for the systems with central (plasma) drug elimination. The following equation, V ss
A discretized population balance for continuous systems at steady state
β Scribed by Michael J. Hounslow
- Publisher
- American Institute of Chemical Engineers
- Year
- 1990
- Tongue
- English
- Weight
- 889 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0001-1541
No coin nor oath required. For personal study only.
β¦ Synopsis
This paper is concerned with the solution of the population balance for continuous systems at steady state, in which the active mechanisms are nucleation, growth. and aggregation. A discretized population balance, initially proposed by Hounslow et al. (1988a) for batch systems, is adapted for use with continuous systems at steady state. It is shown that simultaneous nucleation and growth can be described very effectively by the discrete equations. Criteria are developed for the selection of the optimal size domain. A simple modification to the original discrete equations describing growth, permits the modelling of size-dependent growth effects. Both size-independent and size-dependent aggregation are described by the discrete equations with three significant-figure accuracy. The complete set of discrete equations is used to simulate the nucleation, growth and aggregation of Nickel Ammonium Sulphate. It is shown that analysis by the approximate model must lead to underestimation of the nucleation and growth rates.
π SIMILAR VOLUMES
This paper has developed a recursive least squares scheme for operating a class of continuous fermentation processes at the optimal steady state productivity. More precisely, the class of continuous fermentation processes under investigation is described by a widely accepted non-segregated fermentat
Polymerization of ethylene in a CSTR using a combined metallocene catalyst system (combination of an open-face catalyst, such as Constrained Geometry Catalyst, and a conventional metallocene catalyst) was studied. Using the model developed by Soares and Hamielec, and expanded by Beigzadeh et al., a