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A discontinuous hammerhead ribozyme embedded in a mammalian messenger RNA

✍ Scribed by Martick, Monika; Horan, Lucas H.; Noller, Harry F.; Scott, William G.


Book ID
109897560
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
429 KB
Volume
454
Category
Article
ISSN
0028-0836

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## Abstract Antisense technology, including ribozyme and small interfering RNA, is being developed to mediate the down‐regulation of specific intracellular genes. It was observed in this study that both antiluciferase ribozymes and short hairpin RNAs (shRNAs) could significantly reduce the activity