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A direct synthesis of β-carbolines via a three-step one-pot domino approach with a bifunctional Pd/C/K-10 catalyst

✍ Scribed by Aditya Kulkarni; Mohammed Abid; Béla Török; Xudong Huang

Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
781 KB
Volume
50
Category
Article
ISSN
0040-4039

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✦ Synopsis

A rapid, microwave-assisted synthesis of b-carbolines via a successive condensation/cyclization/dehydrogenation approach is described. This methodology involves the coupling of various tryptamines with aromatic aldehydes/glyoxals. The product imine undergoes a Pictet-Spengler cyclization followed by a final dehydrogenation to yield b-carbolines in a three-step domino reaction. The use of the bifunctional catalyst Pd/C/K-10 combined with microwave irradiation enabled the synthesis of b-carbolines in short reaction times and in good to excellent yields.

📜 SIMILAR VOLUMES

ChemInform Abstract: A Direct Synthesis
ChemInform Abstract: A Direct Synthesis of β-Carbolines via a Three-Step One-Pot Domino Approach with a Bifunctional Pd/c/K-10 Catalyst.
✍ Aditya Kulkarni; Mohammed Abid; Bela Toeroek; Xudong Huang 📂 Article 📅 2009 🏛 John Wiley and Sons ⚖ 24 KB 👁 1 views

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