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A direct interaction between the adaptor protein Cbl-b and the kinase Zap-70 induces a positive signal in T cells

✍ Scribed by Zhihong Zhang; Chris Elly; Ling Qiu; Amnon Altman; Yun-Cai Liu


Book ID
114321437
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
119 KB
Volume
9
Category
Article
ISSN
0960-9822

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## Abstract TCR signaling leads to the activation of kinases such as inducible tyrosine kinase (Itk), a key regulatory protein in T‐lymphocyte activation and function. The homolog of Itk in B cells is Bruton's tyrosine kinase, previously shown to bind and phosphorylate the transcription factor TFII