Direct Transformation of the Second Exci
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Dr. D. Bryce-Smith; Dr. A. Gilbert; Prof. D. A. Robinson
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Article
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1971
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John Wiley and Sons
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English
⚖ 239 KB
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However, treating 2-lithiothiophene with quinoline at 20°C by Giiman's methodf6] leads only to 2-(2-thienyl)quinoline (2) (38%), indicating steric hindrance of 4-addition by the peri-hydrogen atom of the quinoline. In the following reactions of the quinoline system with 2-lithiothiophene derivatives