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A Direct Catalytic Asymmetric Aldol Reaction of α-Sulfanyl Lactones: Efficient Synthesis of SPT Inhibitors

✍ Scribed by Sho Takechi ; Dr. Shigeo Yasuda; Dr. Naoya Kumagai; Prof. Dr. Masakatsu Shibasaki


Book ID
112000868
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
704 KB
Volume
51
Category
Article
ISSN
0044-8249

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## Abstract An easily available and efficient chiral __N__,__N__′‐dioxide–nickel(II) complex catalyst has been developed for the direct catalytic asymmetric aldol reaction of α‐isothiocyanato imide with aldehydes which produces the products in morderate to high yields (up to 98 %) with excellent di