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A Direct Approach to the Synthesis of Famciclovir and Penciclovir

✍ Scribed by Choudary, Bernadette M.; Geen, Graham R.; Kincey, Peter M.; Parratt, Martin J.; Robert, J.; Dales, M.; Johnson, Graham P.; O'Donnell, Steven; Tudor, David W.; Woods, Neil


Book ID
120491057
Publisher
Taylor and Francis Group
Year
1996
Tongue
English
Weight
661 KB
Volume
15
Category
Article
ISSN
0732-8311

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Direct approach to the bakkanes: A synth
✍ Fernando Coelho; Jean-Pierre DeprΓ©s; Timothy J. Brocksom; Andrew E. Greene πŸ“‚ Article πŸ“… 1989 πŸ› Elsevier Science 🌐 French βš– 159 KB

A short synthesis of racemic homogynolide-B is described. The key step of the approach, cycloaddition of dichloroketene with the 2,2-dimethyltrimethylene acetal of 2,3-dimethyl-3-cyclohexen-l-one, proceeds with excellent selectivity and in high yield. The bakkanes, a relatively small group of hydri