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A Dimerization “Switch” in the Internalization Mechanism of a Cell-Penetrating Peptide

✍ Scribed by Moss, Jason A.; Lillo, Antonietta; Kim, Young Soo; Gao, Changshou; Ditzel, Henrik; Janda, Kim D.

Book ID
125942833
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
101 KB
Volume
127
Category
Article
ISSN
0002-7863

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## Abstract The cell‐penetrating peptide Tat (48–60) (GRKKRRQRRRPPQ) derived from HIV‐1 Tat protein showed potent antibacterial activity (MIC: 2–8 µM). To investigate the effect of dimerization of Tat (48–60) analog, [Tat(W): GRKKRRQRRRPWQ‐NH~2~], on antimicrobial activity and mechanism of bacteric