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A diffusion-ordered NMR spectroscopy study of the solubilization of artemisinin by octanoyl-6-O-ascorbic acid micelles

✍ Scribed by Anna Rita Bilia; M. Camilla Bergonzi; Francesco F. Vincieri; Pierandrea Lo Nostro; Gareth A. Morris

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 90 KB
Volume: 91
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.10217

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✦ Synopsis

Artemisinin (QHS) is a natural drug with a very low solubility in water. To improve its availability in hydrophilic media, it was solubilized in micellar dispersions of octanoyl-6-O-ascorbic acid (ASC8), a relatively novel surfactant that combines surface activity with powerful performance as radical scavenger. In this article we report a study based on diffusion-ordered NMR spectroscopy (DOSY) measurements carried out on QHS/ASC8 micellar dispersions. QHS is efficiently solubilized by ASC8 micelles, with no significant perturbation of the micellisation.

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