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A Different Role of Meldrum's Acid in the Biginelli Reaction

✍ Scribed by Jan Svĕtlík; Lucia Veizerová

Publisher
John Wiley and Sons
Year
2011
Tongue
German
Weight
172 KB
Volume
94
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

A Biginelli‐type condensation using Meldrum's acid has been accomplished in refluxing AcOH to give 6‐substituted dihydropyrimidine‐2,4‐(1__H__,3__H__)‐diones. In contrast to other aldehydes, the three‐component reaction with salicylaldehyde led to an oxygen‐bridged pyridine. A reaction mechanism is proposed.

📜 SIMILAR VOLUMES

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