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A difference in the in vivo cerebral production of [1-14C] lactate from D-[3-14C] glucose in chronic mental patients

✍ Scribed by Dr. William Sacks; David C. Schechter; Shirley Sacks

Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
674 KB
Volume
6
Category
Article
ISSN
0360-4012

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✦ Synopsis

Abstract

Data from a study in which 12 chronic mental patients and 12 control subjects were given D‐[3‐^14^C] glucose intravenously in our arterio‐venous technique for determining cerebral metabolism in vivo were reexamined. Previously unpublished whole‐blood lactate determinations in these experiments indicated a cerebral production of much higher specific activity of [1‐^14^C]‐lactate from the D‐[3‐^14^C] glucose by mental patients. Of several possible explanations offered for this difference, the most likely was that involving a small lactate compartments(s) in some specific region(s) in which decarboxylation of the endogenously formed cerebral lactate was partially inhibited. Two other experiments with mental patients (one given [U‐^14^C] glucose and the other, [1‐^14^C] glucose) whose extraordinary results were described, in part, in a previous report, were interpreted as more extreme examples of the production of higher specific activity ^14^C‐lactate from ^14^C‐glucose by mental patients' brains upon their very unusual whole blood lactate data.

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