A diastereoselective total synthesis of the sesquiterpene (±)-mutisianthol

✍ Scribed by Helena M.C Ferraz; Andrea M Aguilar; Luiz F Silva Jr.

• Book ID: 104205573
• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 168 KB
• Volume: 59
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(03)00974-8

✦ Synopsis

The total synthesis of the phenolic sesquiterpene mutisianthol has been accomplished in 12 steps from the readily available 2methylanisole. The required trans-1,3-disubstituted indan intermediate was obtained through a diastereoselective thallium(III) mediated ring contraction of a 1-methyl-1,2-dihydronaphthalene derivative.