A diastereoselective synthesis of benzopyrans using a novel intramolecular Nicholas reaction in the key cyclisation step
β Scribed by John Berge; Stephen Claridge; Alastair Mann; Christophe Muller; Elizabeth Tyrrell
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 130 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
β¦ Synopsis
A novel intramolecular cyclisation reaction between an organocobalt stabilised cation and a trisubstiluted alkene was accomplished to afford a new family of benzopyran derivatives.
π SIMILAR VOLUMES
A Diastereoselective Cobalt-Mediated Synthesis of Benzopyrans Using a Novel Variation of an Intramolecular Nicholas Reaction in the Key Cyclization Step: Optimization and Biological Evaluation. -A variation of the Nicholas reaction between a hexacarbonyldicobalt-stabilized cation and a trisubstitut
Pyrimethamine 1 is a folic acid reductase inhibitor. In this molecule the ring nitrogen is flanked by two functional groups, which is essential to the biological activity of pyrimethamine. Also, a plethora of aminopterin 2 and 2,4-diamino-6-substituted quinazoline antifolates 3 exhibit strong antima