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A Designed Four-α-Helix Bundle That Binds the Volatile General Anesthetic Halothane with High Affinity

✍ Scribed by Johansson, Jonas S.; Scharf, Daphna; Davies, Lowri A.; Reddy, Konda S.; Eckenhoff, Roderic G.


Book ID
118513825
Publisher
Biophysical Society
Year
2000
Tongue
English
Weight
292 KB
Volume
78
Category
Article
ISSN
0006-3495

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Towards a three-α-helix bundle protein t
✍ Gavin A. Manderson; Jonas S. Johansson 📂 Article 📅 2004 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 534 KB

## Abstract The general anesthetics halothane and chloroform are capable of binding to synthetic water‐soluble four‐α‐helix bundles, which model the putative in vivo receptors. In this study, we investigate the binding of these anesthetics to synthetic water‐soluble three‐α‐helix bundles. A series