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A deleted extra chromosome 22 identified by DNA replication banding

โœ Scribed by M. Parslow; J. J. Hoo; Miriam Garry; Flora Rose


Book ID
104705767
Publisher
Springer
Year
1980
Tongue
English
Weight
959 KB
Volume
53
Category
Article
ISSN
0340-6717

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The identification of homozygous deletions in sporadic neoplasms has been pivotal in the positional cloning of several tumor suppressor genes. Chromosomal arm 18q harbors the DPC4, SMAD2, and DCC genes and is suspected on the basis of high frequencies of allelic loss to harbor additional tumor suppr