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A Degradable Polyethylenimine Derivative with Low Toxicity for Highly Efficient Gene Delivery

โœ Scribed by Forrest, M. Laird; Koerber, James T.; Pack, Daniel W.

Book ID
120211566
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
124 KB
Volume
14
Category
Article
ISSN
1043-1802

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## Background: Poly(ethylene imine) (pei) is a widely used transfection reagent for mammalian cells, but in vivo application of pei 25 kda is restricted by its toxicity. low molecular weight (lmw) pei is less toxic, but also less efficient than its high molecular weight equivalent, and prone to agg