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A Defective, Rearranged Epstein-Barr Virus Genome in EBER-Negative and EBER-Positive Hodgkin's Disease

โœ Scribed by Yan-Jun Gan; Bassem I. Razzouk; Tao Su; John W. Sixbey

Book ID
117022441
Publisher
American Society for Investigative Pathology
Year
2002
Tongue
English
Weight
392 KB
Volume
160
Category
Article
ISSN
0002-9440

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Hodgkin's disease (HD) is a malignant lymphoproliferative disease characterized by the presence of HodgkinยฑReedยฑSternberg cells surrounded by a reactive inยฎltrate. In EpsteinยฑBarr virus (EBV)-associated cases (40ยฑ60%), at least two EBV-encoded proteins [latent membrane protein 1 (LMP1) and LMP2] are