✦ LIBER ✦

A de novo Philadelphia chromosome-positive acute mixed-lineage leukemia with both major and minor BCR/ABL mRNA transcripts

✍ Scribed by Takahisa Tarumoto; Shigehiko Imagawa; Ken Ohmine; Atsushi Mano; Tadashi Nagai; Masaaki Takatoku; Kazuo Muroi; Kiyohiko Hatake; Keiya Ozawa

Book ID: 101318866
Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 91 KB
Volume: 65
Category: Article
ISSN: 0361-8609
DOI: 10.1002/1096-8652(200009)65:1<72::aid-ajh13>3.0.co;2-r

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✦ Synopsis

A patient with a Philadelphia chromosome (Ph)-positive acute mixed-lineage leukemia (AMLL) expressing both major and minor BCR/ABL mRNA transcripts is described. Phenotypic analysis of the leukemic blasts revealed positivity for both myeloid and B-cell lineages. Southern blot analysis showed a rearrangement of the immunoglobulin heavy chain (IgH) gene. Reverse transcriptase polymerase chain reaction (RT-PCR) analysis showed the expression of both major and minor BCR/ABL mRNA transcripts. To our knowledge, this is the first report of AMLL expressing both major and minor BCR/ABL mRNA transcripts and rearrangement of the IgH gene. Am.

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We studied the efficacy and pharmacokinetics of imatinib mesylate (IM) and bcr-abl expression in a Philadelphia chromosome-positive acute myeloid leukemia (Ph + AML) patient, a rare disease with a poor prognosis. Although sufficient IM trough concentrations were maintained, bcr-abl transcripts revea