✦ LIBER ✦

A Cycle of Enzymatic Reactions that Behaves like a Neuronal Circuit

✍ Scribed by JAN SIELEWIESIUK; ELZBIETA MALARCZYK

Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 310 KB
Volume: 214
Category: Article
ISSN: 0022-5193
DOI: 10.1006/jtbi.2001.2451

No coin nor oath required. For personal study only.

✦ Synopsis

A cycle of four enzymatic reactions with repression or allosteric inhibition of the enzymes has been proposed by analogy to a neural oscillator. The system is analysed in a situation remote from full symmetry. Asymmetry has been introduced by treating one of the reagents as a reservoir substance with constant concentration and having essentially di!erent rate constants for forward and backward reactions. It is demonstrated that, for certain values of parameters, the system can work as a strength of stimulus to frequency transducer. For other values of the parameters, it acquires the features of an excitable system.

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