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A crystal molecular conformation of leucine-enkephalin related to the morphine molecule

✍ Scribed by A. Aubry; N. Birlirakis; M. Sakarellos-Daitsiotis; C. Sakarellos; M. Marraud

Publisher: Wiley (John Wiley & Sons)
Year: 1989
Tongue: English
Weight: 868 KB
Volume: 28
Category: Article
ISSN: 0006-3525
DOI: 10.1002/bip.360280106

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✦ Synopsis

Synopsis

Leucine-enkephalin (Try1-Gly2-Gly3-Phe4-Leu5) has been crytallized as a trihydrate from water solution. X-ray diffraction reveals a tightly folded molecular conformation with two fused BIII-(Gly2-Gly3) and BI-(Gly3-Phe4) turns. The Tyr' and Phe4 aromatic rings have a close orthogonal arrangement analogous to the tyramine and cyclohexenyl rings in morphine. This suggests that the conformation found in the trihydrate crystal structure could be required for recognition by preceptor sites.

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