✦ LIBER ✦

A critique of the false-positive report probability

✍ Scribed by Joseph F. Lucke

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 104 KB
Volume: 33
Category: Article
ISSN: 0741-0395
DOI: 10.1002/gepi.20363

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The false positive report probability (FPRP) was proposed as a Bayesian prophylactic against false reports of significant associations. Unfortunately, the derivation of the FPRP is unsound. A heuristic derivation fails to make its point, and a formal derivation reveals a probabilistic misrepresentation of an observation. As a result, the FPRP can yield serious inferential errors. In particular, the FPRP can use an observation that is many times more likely under the null hypothesis than under the alternative to infer that the null hypothesis is far less probable than the alternative. Contrary to its intended purpose, the FPRP can promote false positive results. It should not be used. A modified FPRP is derived, but it appears to have limited application and does not address the problem of false reports of significant associations. The conditional error probability is a possible replacement for the FPRP. Genet. Epidemiol. 2008. © 2008 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

False-positive maternal serum screening

False-positive maternal serum screening in systemic lupus erythematosis: a case report

✍ E. L. Ferriman; I. K. Sehmi; R. Jones; A. Railton; R. C. Hilton; H. S. Cuckle 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 38 KB 👁 2 views

Corporate crime: A critique of the clina

Corporate crime: A critique of the clinard report

✍ T. R. Young 📂 Article 📅 1981 🏛 Springer 🌐 English ⚖ 939 KB

False Alarm Probability of a DWT-Based E

False Alarm Probability of a DWT-Based Estimation Algorithm

✍ Joseph P. Noonan; David A. Marquis 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 145 KB

type II error, is also important. A false alarm occurs when signal is declared present when the input con-Recently, the wavelet transform has been applied to the sists of only noise. This paper derives the probability problem of detecting and estimating transient signals in of false alarm for the al

The false positive technetium-99m hepati

The false positive technetium-99m hepatic scintiscan

✍ J. A. Volpe; E. T. Morita; G. S. Johnston 📂 Article 📅 1969 🏛 John Wiley and Sons 🌐 English ⚖ 386 KB

False-positive reporting of Down syndrom

False-positive reporting of Down syndrome on Ohio and New York birth certificates

✍ Karen M. Johnson; Carl A. Huether; Ernest B. Hook; Carol A. Crowe; Barbara A. Re 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 580 KB

Although correction for underreporting of congenital malformations on birth certificates is included in most studies, inaccuracy of reporting has not been widely examined. Two separate investigations were conducted on the inaccuracy of Down syndrome (DS) reporting on birth certificates; ie, false-po

A FALSE-POSITIVE DIAGNOSIS OF TURNER SYN

A FALSE-POSITIVE DIAGNOSIS OF TURNER SYNDROME BY AMNIOCENTESIS

✍ M. J. GRIFFITHS; P. R. MILLER; H. M. STIBBE 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 316 KB 👁 2 views

A 45,X karyotype was observed in all cells examined from an amniotic 0uid sample taken at 16 weeks' gestation from a 37-year-old patient referred because of her age. Following termination of the pregnancy, all cells examined from fetal tissues (cardiac blood, skin, and muscle) showed a 46,XX karyoty