A critical role of PI-3K/Akt/JNKs pathway in benzo[a]pyrene diol-epoxide (B[a]PDE)-induced AP-1 transactivation in mouse epidermal Cl41 cells

Benzo[a]pyrene diol-epoxide (B[a]PDE) up

Benzo[a]pyrene diol-epoxide (B[a]PDE) upregulates COX-2 expression through MAPKs/AP-1 and IKKβ/NF-κB in mouse epidermal Cl41 cells

✍ Weiming Ouyang; Qian Ma; Jingxia Li; Dongyun Zhang; Jin Ding; Yi Huang; Mingzhao 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 349 KB

## Abstract Benzo[α]pyrene‐7,8‐diol‐9,10‐epoxide (B[a]PDE), the major metabolite of benzo[a]pyrene (B[a]P), shows an ultimate complete carcinogen in various animals and is a causative agent for human cancers. However, its effects on the activation of signal pathways and the expression of genes invo