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A critical role for interleukin 4 in activating alloreactive CD4 T cells

✍ Scribed by Bagley, Jessamyn; Sawada, Tokihiko; Wu, Yin; Iacomini, John


Book ID
109829055
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
122 KB
Volume
1
Category
Article
ISSN
1529-2908

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CD4, CD8 and CD45 regulate the coupling of the T-cell receptor complex (CD3-TCR) to tyrosine kinase activation and phosphorylation of key substrates such as phospholipase C gamma 1. CD4 and CD8 contribute to activation signals through their cytoplasmic association with p56lck. Expression of the zeta