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A Critical Role for Dnmt1 and DNA Methylation in T Cell Development, Function, and Survival

✍ Scribed by Peggy P. Lee; David R. Fitzpatrick; Caroline Beard; Heidi K. Jessup; Sophie Lehar; Karen W. Makar; Mercedes Pérez-Melgosa; Marianne T. Sweetser; Mark S. Schlissel; Suzanne Nguyen; Sara R. Cherry; Jeff H. Tsai; Sean M. Tucker; William M. Weaver; Anne Kelso; Rudolf Jaenisch; Christopher B. Wilson


Book ID
117723136
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
846 KB
Volume
15
Category
Article
ISSN
1074-7613

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## Abstract Transcriptional silencing during differentiation of human male germ cells and serum starvation of human fibroblasts is controlled by epigenetic mechanisms that involve de novo DNA methylation. It is associated with high expression of different trancripts of the DNA methyltransferase 3A