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A critical review of evidence for preclinical differences between rasagiline and selegiline

✍ Scribed by Manfred Gerlach; Heinz Reichmann; Peter Riederer

Book ID
119192869
Publisher
Elsevier
Year
2012
Tongue
English
Weight
253 KB
Volume
2
Category
Article
ISSN
2210-5336

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## Abstract The ADAGIO study demonstrated a symptomatic benefit for rasagiline in early Parkinson's disease (PD) and suggested a disease‐modifying effect. Evidence indicates that mitochondrial dysfunction plays a role in the pathogenesis of PD and that this may be the site of effect for rasagiline.