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A CRE and the region occupied by a protein induced by growth factors contribute to up-regulation of cyclin D1 expression in hepatocytes

โœ Scribed by Akihiro Moriuchi; Akio Ido; Yoshiko Nagata; Kenji Nagata; Hirofumi Uto; Satoru Hasuike; Takeshi Hori; Shuichi Hirono; Katsuhiro Hayashi; Hirohito Tsubouchi


Book ID
117053080
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
246 KB
Volume
300
Category
Article
ISSN
0006-291X

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## Abstract Strong activation of the ERK signal is required for hepatocyte growth factor (HGF) to inhibit proliferation of the human hepatocellular carcinoma cell line HepG2. However, it is still to be elucidated whether the activation alone is sufficient to induce the inhibitory effect. In this st