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A Coupling of Structural and Kinetic Models Reveals the Stepping Mechanics of Dynein

✍ Scribed by Tsygankov, Denis; Serohijos, Adrian W.R.; Dokholyan, Nikolay V.; Elston, Timothy C.


Book ID
122233922
Publisher
Biophysical Society
Year
2010
Tongue
English
Weight
48 KB
Volume
98
Category
Article
ISSN
0006-3495

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A model of fast axonal transport of organelles that accounts for dynein transport in an inactive state toward the axonal synapse is developed. It is assumed that anterograde transport of inactive dynein in an axon is powered by kinesin motors. It is further assumed that the probability of organelle