✦ LIBER ✦
A correlation with type of sulfonamide resistance gene in Escherichia coli and synergy between trimethoprim and sulfamethoxazole
✍ Scribed by Dr. Carrie R. Valentine; James M. Hawk; Mary M. Christian; Roger W. Youmans
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 350 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0233-111X
No coin nor oath required. For personal study only.
✦ Synopsis
Plasmids carrying type I or I1 sulfonamide-resistance (Su') genes were evaluated for their effect on synergy between trimethoprim (Tmp) and sulfamethoxyzole (Smx) in E. coli. Strain 553 containing each of three plasmids (Rl, pSu, and R388) with the type I Su' gene displayed a synergistic response to Tmp/Smx; strain LE392 containing a plasmid (RSF1010) with the type I1 Su' gene displayed no synergy. The difference in synergy between type I and type I1 Su' genes might be explained by the diKerence in amount of resistant enzyme produced.