A Copper Coordination Compound Produced by a Marine Fungus Fusarium sp. ZZF51 with Biosorption of Cu(II) Ions

✍ Scribed by Ni TAN; Jia-Hui PAN; Guang-Tian PENG; Cheng-Bo MOU; Yi-Wen TAO; Zhi-Gang SHE; Ze-Liang YANG; Shi-Ning ZHOU; Yong-Cheng LIN

• Book ID: 102095831
• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 155 KB
• Volume: 26
• Category: Article
• ISSN: 0256-7660
• DOI: 10.1002/cjoc.200890097

✦ Synopsis

Abstract

A copper coordination compound ZZF51(A) named bis(5‐butyl‐2‐pyridinecarboxylato‐N1,O2)‐copper, the first time found in the nature, was isolated from a marine endophytic fungus Fusarium sp. ZZF51 from the South China Sea coast. Its structure was elucidated using spectroscopic methods and single crystal X‐ray diffraction analysis. The antimicrobial cytotoxicity experiments exhibited that ZZF51(A) had mutagenicity activities against four aerobic reference strains Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Salmonella enteritidis with respective MIC values of 12.5, 25, 12.5, and 50 µg/mL. The anti‐cancer tests showed that the compound had strong inhibitory activities against three human cancer lines KB, KBv200, and HepG2 with IC~50~ values of 3.54, 3.68 and 25.12 µg/mL respectively. In the course of investigating the source of ZZF51(A) in biomass, it was found that the output of ZZF51(A) was largely influenced by the amount of CuCl~2~ in the liquid medium, and the fungus (No. ZZF51) had two notable characteristics:endurance of high concentration Cu(II) ions and biosorption of Cu(II) ions.