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A convergent synthesis of the renin inhibitor SPP-100 using a nitrone intermediate

✍ Scribed by Alessandro Dondoni; Geert De Lathauwer; Daniela Perrone

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
74 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

The total synthesis of SPP-100 and its C-5 epimer involves the construction of the b-amino alcohol segment via addition of the Grignard reagent derived from 3-aryl-2-isopropyl-1-chloropropane to the nitrone functional group installed at C-4 of the pseudoephedrine spiroanellated g-butyrolactone derivative.

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