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A Convenient Synthesis of α,β-Acetylenic Ketones

✍ Scribed by Li, Pei; Fong, Wai Man; Chao, Lisa C. F.; Fung, Stephen H. C.; Williams, Ian D.


Book ID
111891432
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
63 KB
Volume
66
Category
Article
ISSN
0022-3263

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The reaction of terminal acetylenic ketones with NaI or LiBr gave almost exclusively E-B-iodo-or E-8-bromovinyl ketones in trifluoroacetic acid, while Z-Biodo-or Z-B-bromovinyl ketones were the major products in acetic acid. Trimethylsilyl iodide and oromide reacted smoothly with acetylenic ketones