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A convenient synthesis of the novel carboranyl-substituted tetrahydroisoquinolines: application to the biologically active agent for BNCT

✍ Scribed by Jong-Dae Lee; Chai-Ho Lee; Hiroyuki Nakamura; Jaejung Ko; Sang Ook Kang

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 96 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)01034-1

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✦ Synopsis

A convenient method for o-carborane-substituted tetrahydroisoquinolines (THIQ) is described; in particular, compound 8c accumulates in B-16 melanoma cells with a significantly high level although its cytotoxicity is significantly low.

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