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A convenient synthesis of symmetrical N,N′-dialkylureas by the reactions of 4-chloro-5H-1,2,3-dithiazol-5-one with alkylamines

✍ Scribed by Yong-Goo Chang; Hyi-Seung Lee; Kyongtae Kim

Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 86 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)01761-0

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✦ Synopsis

Treatment of 4-chloro-5H-1,2,3-dithiazol-5-one with primary and secondary alkylamines (>2 equiv.) in CH 2 Cl 2 at rt afforded symmetrical N,N%-disubstituted ureas in moderate to good yields. Similarly, the reactions with amino acid ester hydrochlorides in the presence of Et 3 N (>3 equiv.) under the same conditions gave symmetrical ureas.

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