A convenient synthesis of stereochemically pure retinoids. The synthesis of 10,14-dimethyl retinals.

✍ Scribed by Steven P. Tanis; Robert Hallam Brown; Koji Nakanishi

• Book ID: 104242611
• Publisher: Elsevier Science
• Year: 1978
• Tongue: French
• Weight: 244 KB
• Volume: 19
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)91422-4

✦ Synopsis

As part of our continuing studies of retinals and visual pigments, 2 we desired relatively large quantities of stereochemically pure retinoids.

In particular, we desired the various geometric isomers of lo-methyl, 14-methyl and 10,14-dimethyl retinals (1,2,3),3 since these ,X.&Y are useful in studies directed toward the clarification of the steric factors involved in 2 3

visual pigment formation.

2,4 The recent interest in retinoids as anticancer agents5 has also stimulated research into the effect of modifications in the Vitamin-A skeleton upon the therapeutic and toxic properties of retinoids.