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A Convenient Synthesis of Protected α-Hydroxyacetaldehydes

✍ Scribed by Shiao, Min-Jen; Yang, Chia-Yu; Lee, Shi-Hung; Wu, Teh-Chun


Book ID
121082442
Publisher
Taylor and Francis Group
Year
1988
Tongue
English
Weight
218 KB
Volume
18
Category
Article
ISSN
0039-7911

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Boc-(R)-ot-phenylproline ethyl ester 1 was prepared in good yield starting from racemic phenylglycine. Condensation of phenylglycine ethyl ester with benzaldehyde furnished N-benzylidene phenylglycine ethyl ester which was allylated under phase transfer catalysis conditions. After acidic hydrolysis,