A convenient synthesis of naturally occurring benzofuran ailanthoidol
โ Scribed by Chai-Lin Kao; Ji-Wang Chern
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 86 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
A convenient method for the synthesis of ailanthoidol starting from vanillin is provided using trimethylsilyldiazomethane lithium salt to generate a diphenylacetylene and subsequent oxymercuration cyclization of the resulting alkyne with mercury acetate in acetic acid as key steps.
๐ SIMILAR VOLUMES
I'mted 8x1 Cm11 Bnta~n. B. SIMOSLW and P. BILASSA~D 781 yield OP the corresponding products in a 2.9: 1.0 ratio). A combination consisting largely oP the E-isomer could also be obtained by the use oP trimethylsilyl triilate in triethylamine" but the yield did not exceed 561. Analogoua compounds ha
A general method of synthesis of 2-aryl-7-alkoxy-benzofurans is described using a benzoannulation reaction as key step. The usefulness of this approach is shown in the new synthesis of ailanthoidol, a benzofuranoid neolignan isolated from the tree Zanthoxylum ailanthoides.