✦ LIBER ✦

A Convenient Synthesis of Centperazine, an Antifilarial Candidate Drug

✍ Scribed by Sengupta, Sreela ;Sahu, Devi Prasad ;Chatterjee, Sunil Krishna

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 279 KB
Volume: 1993
Category: Article
ISSN: 0947-3440
DOI: 10.1002/jlac.199319930171

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

7‐Ethyl‐octahydro‐2‐methyl‐6__H__‐pyrazino[1,2‐c]pyrimidin‐6‐one (centperazine) (1), an antifilarial candidate drug, currently undergoing phase II clinical trials, has been synthesized by a more economically viable alternative route. Condensation of N,N′‐dibenzylethylenediamine (2) with 3,4‐dibromobutyronitrile (3) gives 2‐(1,4‐dibenzyl‐2‐piperazinyl)acetonitrile (4), which, on catalytic reduction, debenzylation, cyclocarbamation and N‐alkylation yields the target molecule 1 in 10.1% overall yield.

📜 SIMILAR VOLUMES

A Convenient Synthesis of Nabumetone — A

A Convenient Synthesis of Nabumetone — An Antiinflammatory Drug Candidate.

✍ G. Srinivasulu; A. Raghupathi Reddy; Ch. Nagaraju; P. Pratap Reddy; M. Satyanara 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 14 KB

ChemInform Abstract: A Practical Synthes

ChemInform Abstract: A Practical Synthesis of 7-Ethyl-octahydro-2-methyl-6H-pyrazino[1,2-c]pyrimidin-6-one (Centperazine), an Antifilarial Drug.

✍ Devi Prasad Sahu 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB

Stereoselective synthesis of an anti-HIV

Stereoselective synthesis of an anti-HIV drug candidate

✍ David A. Conlon; Mark S. Jensen; Michael Palucki; Nobuyoshi Yasuda; Joann M. Um; 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 197 KB

An Efficient Implementation of a Drug Ca

An Efficient Implementation of a Drug Candidate Database.

✍ Zina Ben Miled; Yang Liu; David Powers; Omran Bukhres; Michael Bem; Robert Jones 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 52 KB

ChemInform Abstract: A Simple and Conven

ChemInform Abstract: A Simple and Convenient Synthesis of (.+-.)-Methylcyclopentanone-3-carboxylate; an Important Precursor of Antitumor Drug Sarkomycin.

✍ L. Srinivasula Reddy; N. C. Gangi Reddy; T. Ram Reddy; Y. Lingappa; K. S. V. Kri 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 22 KB 👁 1 views

An integrated process for measuring the

An integrated process for measuring the physicochemical properties of drug candidates in a preclinical discovery environment

✍ Christopher E. Kibbey; Salwa K. Poole; Ben Robinson; J. Derek Jackson; Douglas D 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 257 KB 👁 1 views

Automated log P, pK a , solubility, and chemical stability systems comprise an integrated process that provides early stage physicochemical property data to the discovery research organization. Capillary electrophoresis (CE) techniques are used to experimentally determine pK a and log P. Solubility