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A convenient synthesis of azido peptides by post-assembly diazo transfer on the solid phase applicable to large peptides

✍ Scribed by Dirk T.S. Rijkers; H.H.Ricardo van Vugt; Hans J.F. Jacobs; Rob M.J. Liskamp

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 191 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)00629-9

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✦ Synopsis

An efficient method for the conversion of solid phase bound peptide amines into azides by a diazo transfer using triflyl azide in the presence of divalent copper ions is described. a-Azido acids and azido peptides-up to 30 amino acids in length-are obtained in good yields and high purities after cleavage from the solid support.

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