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A Convenient Synthesis of Amino Acid Methyl Esters

✍ Scribed by Li, Jiabo; Sha, Yaowu

No coin nor oath required. For personal study only.

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Esters having tj-alkyl-N-acyl (or thioacyl) functionality at the d-position are smoothly reduced with NaBH4-MeOH at 0-5'C in very good yields.