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A convenient synthesis of 4-hydroxy-2-pyridone

โœ Scribed by Robert L. Shone; Virgil M. Coker; Alan E. Moormann


Book ID
112123425
Publisher
Journal of Heterocyclic Chemistry
Year
1975
Tongue
English
Weight
96 KB
Volume
12
Category
Article
ISSN
0022-152X

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โœ Ian Collins; JosรฉL. Castro ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 235 KB

A rapid and convenient synthesis of the 3-trifluoromethanesuifonyloxy-2-pyridone 2, one of the first examples of this class of compound, was achieved by Vilsmeier formylation and cyclisation of the acyl enamine 6. The triflate 2 was found to undergo a range of palladium-catalysed coupling reactions