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A convenient synthesis of 3-iodohomoallylic alcohols and the further transformation to α,β-unsaturated γ-lactones

✍ Scribed by Chunming Zhang; Xiyan Lu

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
157 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

The tandem nucleophilic addition-aldol reaction of 3,4-pentadien-2-one, iodide ion, and aldehydes in the presence of ZrCI4 as the catalyst gave the 3-iodohomoallylic alcohols in good yields, which could be further transformed to or,IS-unsaturated y-lactones by palladium-catalysed cyclocarbonylation.

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