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A Convenient Synthesis of 2-Substituted 3-Hydroxy- and 3-Amino-Thiophens from Derivatives of 2-Chloroacrylic Acid

✍ Scribed by Huddleston, Patrick R; Barker, John M.


Book ID
120976140
Publisher
Taylor and Francis Group
Year
1979
Tongue
English
Weight
163 KB
Volume
9
Category
Article
ISSN
0039-7911

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A stereoselective chemoenzymatic synthesis of Fmoc-protected (2S,3S)-2-hydroxy-3-amino acids 6 is described. After the formation of cyanohydrin 2 from 2-furaldehyde in the presence of R-oxynitrilase and subsequent protection, 3 was transformed into fully protected ethanolamines 5. Ozonolysis provide