Synthesis of 3-aminopyridine-2-carboxald
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Chuansheng Niu; Jun Li; Terrence W. Doyle; Shu-Hui Chen
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Article
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1998
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Elsevier Science
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French
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Palladium-catalyzed cross-coupling of methylboronic acid with 2-chloro-3-nitropyridine produced 2methyl-3-nitropyridine 4 in one step in high yield. Oxidation of 4 with selenium dioxide gave aldehyde 5. Alternatively, condensation of 4 with DMFDMA followed by oxidation gave 5 in a two step higher yi