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A Convenient Procedure for the Methylation of Lovastatin: Synthesis of Simvastatin

✍ Scribed by Dabak, Kadir; Keskin, Hulya


Book ID
111891203
Publisher
Walter de Gruyter GmbH & Co. KG
Year
2004
Tongue
English
Weight
561 KB
Volume
10
Category
Article
ISSN
0793-0283

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πŸ“œ SIMILAR VOLUMES


A convenient procedure for the synthesis
✍ Kung K. Wang; Zhongguo Wang πŸ“‚ Article πŸ“… 1994 πŸ› Elsevier Science 🌐 French βš– 332 KB

Bromoboration of l-hexyne with BBr, followed by treatment with 2-propanol produced alkenyl boronic ester 3. Subsequent Pd(O)-catalyzed cross-coupling with acetylenic zinc chlorides and iodination furnished enyne iodides 6, which were then converted to enyne-allenes 8 by a second Pd(O)-catalyzed reac