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A Convenient Microwave-Enhanced Solid-Phase Synthesis of Difficult Peptide Sequences: Case Study of Gramicidin A and CSF114(Glc)

✍ Scribed by Fabio Rizzolo; Giuseppina Sabatino; Mario Chelli; Paolo Rovero; Anna Maria Papini

Publisher
Springer Netherlands
Year
2007
Tongue
English
Weight
310 KB
Volume
13
Category
Article
ISSN
1573-3149

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## Abstract Structural modification of the peptide backbone via __N__‐methylation is a powerful tool to modulate the pharmacokinetic profile and biological activity of peptides. Here we describe a rapid and highly efficient microwave(MW)‐assisted Fmoc/tBu solid‐phase method to prepare short chain _