A Convenient Method for the Synthesis of the Amphiphilic Triblock Copolymer Poly(L-lactic acid)-block-Poly(L-lysine)-block-Poly(ethylene glycol) Monomethyl Ether

✍ Scribed by Li Xiang; Lin-Jing Shen; Feng Long; Ke Yang; Jun-Bing Fan; Ya-Jing Li; Jiannan Xiang; Ming-Qiang Zhu

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 626 KB
• Volume: 212
• Category: Article
• ISSN: 1022-1352
• DOI: 10.1002/macp.201000717

✦ Synopsis

Abstract

The amphiphilic triblock copolymer PLA__‐b‐PLL‐b‐MPEG is prepared in three steps through acylation coupling between the terminal amino groups of PLA‐b‐__PZLL‐NH~2~ and carboxyl‐terminal MPEG, followed by the deprotection of amines. The block copolymers are characterized via FT‐IR, ^1^H NMR, DSC, GPC, and TEM. TEM analysis shows that the triblock polymers can form polymeric micelles in aqueous solution with a homogeneous spherical morphology. The cytotoxicity assay indicates that the final triblock polymer micelles after deprotection show low cytotoxicity against Bel7402 human hepatoma cells. MPEG and PLL were introduced into the main chain of PLA affording a kind of ideal bioabsorbable polymer materials, which is expected to be useful in drug and gene delivery.
magnified image