Two methods for the preparation of 2-cyc
โ
Mark E. Fraley; Robert S. Rubino
๐
Article
๐
1997
๐
Elsevier Science
๐
French
โ 217 KB
The addition of organolithium or Grignard reagents to vinylogous ester resin l followed by mild hydrolysis of product resins 2 provides 3-alkyl-2-cyclohexenones in high purity (>95%). Alternatively, conversion of 1 to vinyl triflate resin 4 followed by palladium-mediated couplings with aryl boronic